8-methoxykynurenate to n-acetylhistidine

Numerator Metabolite

Structure of 8-methoxykynurenate
Metabolite Accession: GCST90200186
Name: 8-methoxykynurenate
Hmdb Id: HMDB0060426
Super Pathway: NA
Sub Pathway: NA
Inchikey: BXZSKDOPGDPDEG

Denominator Metabolite

Structure of n-acetylhistidine
Metabolite Accession: GCST90199735
Name: n-acetylhistidine
Hmdb Id: HMDB0032055
Super Pathway: NA
Sub Pathway: NA
Inchikey: KBOJOGQFRVVWBH

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.187
Position:
25809069
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
8.263
Reference Allele:
G
-log10(P):
-36.491
MAF:
0.448
Beta (Num):
0.095
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Histidine metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect altered transport by SLC17A4 affecting clearance of both tryptophan and histidine-derived metabolites, though direct transport evidence is lacking.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function likely impacts intestinal urate excretion, directly causing changes in serum uric acid and downstream effects on renal function and hematological traits.10[1], 11[2]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data