tetradecadienoate (14:2)* to stearidonate (18:4n3)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs2727270

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.189
Position:
61603237
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
10.566
Reference Allele:
C
-log10(P):
-58.414
MAF:
0.116
Beta (Num):
0.030
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.159
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Biosynthesis/Metabolism3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Alpha-Linolenic Acid Metabolism6[1], 7[2], 8[3]

Ratio Explanation:

This ratio likely reflects fatty acid desaturase (FADS) enzyme activity; lower FADS2 function may decrease the production of stearidonate (18:4n3), a key omega-3 fatty acid.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster alter fatty acid metabolism, influencing the balance of pro-inflammatory and anti-inflammatory lipids.9[1] This dysregulation is associated with chronic inflammation, a known risk factor for diverticular disease and malignancies of the colon and lung.10[2], 11[3], 9[4], 12[5]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data