tetradecadienoate (14:2)* to myristoylcarnitine (c14)

Numerator Metabolite

Metabolite Accession: GCST90200187

Name: tetradecadienoate (14:2)*

Hmdb Id: HMDB0000560

Super Pathway: NA

Sub Pathway: NA

Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Metabolite Accession: GCST90199730

Name: myristoylcarnitine (c14)

Hmdb Id: HMDB000506

Super Pathway: NA

Sub Pathway: NA

Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs3007691

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

-0.157

Position:

151927901

SE (Ratio):

0.015

Effect Allele:

Z-score (Ratio):

-10.403

Reference Allele:

-log10(P):

-56.692

MAF:

0.400

Beta (Num):

-0.117

Novel Locus:

SE (Num):

0.015

Beta (Den):

0.040

SE (Den):

0.015

No CNV overlap

rQTL cluster:

155

Reaction Distance:

Closest Genes:

S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5^[1], 6^[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7^[1], 8^[2], 9^[3]

Ratio Explanation:

The ratio of tetradecadienoate (14:2) to myristoylcarnitine (C14) may reflect THEM4's thioesterase activity, which influences the pool of myristoyl-CoA available for carnitine conjugation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data