tetradecadienoate (14:2)* to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs61817724

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.139
Position:
151921111
SE (Ratio):
0.011
Effect Allele:
C
Z-score (Ratio):
-12.525
Reference Allele:
A
-log10(P):
-81.194
MAF:
0.315
Beta (Num):
-0.120
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.018
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Long-chain fatty acid metabolism.7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio of tetradecadienoate (14:2) to 10-heptadecenoate (17:1n7) may reflect substrate preference or regulatory activity of the mitochondrial thioesterase THEM4 on fatty acid pools.1[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a link between the gene, metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data