tetradecadienoate (14:2)* to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs2999546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.145
Position:
151907839
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-13.137
Reference Allele:
T
-log10(P):
-89.096
MAF:
0.362
Beta (Num):
-0.121
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.024
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D S100A11

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/beta-oxidation.

Denominator Metabolite Explanation:

Alpha-Linolenic acid metabolism.5[1], 6[2], 7[3], 8[4]

Ratio Explanation:

The ratio may reflect mitochondrial thioesterase activity (THEM4/5), which can hydrolyze acyl-CoAs of varying chain lengths, influencing the balance between different fatty acids.1[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype data is available, so no link can be established between THEM4/5, the tetradecadienoate to linolenate ratio, and a phenotype.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data