tetradecadienoate (14:2)* to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.151
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-10.953
Reference Allele:
G
-log10(P):
-62.610
MAF:
0.318
Beta (Num):
-0.123
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.027
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs2727270

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.186
Position:
61603237
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
9.405
Reference Allele:
C
-log10(P):
-46.709
MAF:
0.116
Beta (Num):
0.030
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.155
SE (Den):
0.024
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis3[1], 4[2]

Ratio Explanation:

The ratio reflects the balance between shorter and longer-chain polyunsaturated fatty acids, influenced by the enzymatic activity of FADS1 and FADS2 desaturases.1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, reflected in the fatty acid ratio, influences lipid profiles and inflammatory responses. This connects to phenotypes like hypercholesterolemia, type 2 diabetes, and cholelithiasis, which are linked to disruptions in lipid metabolism and inflammatory pathways.2[1], 5[2], 6[3], 7[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data