tetradecadienoate (14:2)* to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Metabolite Accession: GCST90200101
Name: pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Hmdb Id: HMDB0013328
Super Pathway: NA
Sub Pathway: NA
Inchikey: NTBUXPPQHCFLOM

Associated Genomic Regions

Region: rs10788817

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.222
Position:
151882856
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-10.176
Reference Allele:
G
-log10(P):
-54.331
MAF:
0.399
Beta (Num):
-0.125
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.098
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D S100A10 RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation; peroxisomal beta-oxidation.4[1]

Denominator Metabolite Explanation:

Dicarboxylic acid metabolism; fatty acid omega-oxidation.5[1], 4[2]

Ratio Explanation:

This ratio compares two dicarboxylic acids.6[1] Altered THEM4 thioesterase activity on dicarboxylyl-CoAs likely affects the balance between these different chain-length fatty acids.3[2], 4[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

A causal link cannot be established as no associated phenotype was provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data