tetradecadienoate (14:2)* to hexadecadienoate (16:2n6)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Associated Genomic Regions

Region: rs2999545

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.112
Position:
151904146
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
-11.699
Reference Allele:
T
-log10(P):
-71.129
MAF:
0.389
Beta (Num):
-0.121
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.010
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4[1]

Denominator Metabolite Explanation:

Fatty acid metabolism.5[1]

Ratio Explanation:

This ratio reflects the balance between a medium-chain (14:2) and a long-chain (16:2n6) fatty acid, potentially modulated by THEM4 thioesterase activity on acyl-CoAs.6[1], 7[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants associated with THEM4 expression may alter mitochondrial fatty acid metabolism, influencing the fatty acid profile.2[1], 6[2], 3[3] This altered lipid environment could affect inflammation or colonic cell integrity, contributing to the development of diverticular disease.9[4], 10[5]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data