tetradecadienoate (14:2)* to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs4845409

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.183
Position:
151894379
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-11.344
Reference Allele:
T
-log10(P):
-67.006
MAF:
0.375
Beta (Num):
-0.125
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.058
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle.7[1], 8[2], 9[3]

Ratio Explanation:

THEM4's thioesterase activity on long-chain acyl-CoAs likely influences the balance between different fatty acid species and their carnitine conjugates for beta-oxidation.3[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype is provided, so no causal link between the gene, the metabolite ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data