tetradecadienoate (14:2)* to stearate (18:0)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.140
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-11.034
Reference Allele:
G
-log10(P):
-63.508
MAF:
0.318
Beta (Num):
-0.123
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.017
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.127
Position:
102075479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-8.235
Reference Allele:
G
-log10(P):
-36.258
MAF:
0.176
Beta (Num):
-0.031
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.4[1]

Ratio Explanation:

An elevated ratio of tetradecadienoate to stearate may indicate increased fatty acid synthesis and desaturation, potentially influenced by SCD activity.1[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SCD activity, reflected by the fatty acid ratio, is linked to dyslipidemia and increased risk for atherosclerosis and cardiovascular diseases.1[1], 5[2], 6[3], 7[4] Higher stearate levels are associated with lower mortality.7[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data