dodecadienoate (12:2)* to 5-dodecenoate (12:1n7)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs55650311

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.157
Position:
2301269
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
9.501
Reference Allele:
C
-log10(P):
-47.618
MAF:
0.158
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
4.35e-04
SE (Den):
0.020
No CNV overlap
rQTL cluster:
35
Reaction Distance:
NA
Closest Genes:
ECI1 RNPS1 AC009065.1 DNASE1L2 E4F1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.3[1], 5[2]

Ratio Explanation:

ECI1 isomerizes various enoyl-CoA species. A higher ratio of dodecadienoate to 5-dodecenoate could suggest altered ECI1 activity impacting unsaturated fatty acid breakdown.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data