dodecadienoate (12:2)* to laurylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90200190

Name: dodecadienoate (12:2)*

Hmdb Id: NA

Super Pathway: NA

Sub Pathway: NA

Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199750

Name: laurylcarnitine (c12)

Hmdb Id: HMDB000225

Super Pathway: NA

Sub Pathway: NA

Inchikey: FUJLYHJROOYKRA

Associated Genomic Regions

Region: rs3007691

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

-0.147

Position:

151927901

SE (Ratio):

0.015

Effect Allele:

Z-score (Ratio):

-9.865

Reference Allele:

-log10(P):

-51.187

MAF:

0.400

Beta (Num):

-0.113

Novel Locus:

SE (Num):

0.015

Beta (Den):

0.034

SE (Den):

0.015

No CNV overlap

rQTL cluster:

155

Reaction Distance:

Closest Genes:

S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.5^[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.6^[1], 7^[2]

Ratio Explanation:

The ratio reflects the balance between C12 fatty acid omega-oxidation and beta-oxidation, which is likely influenced by ACOT2's regulation of the shared lauroyl-CoA pool.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a causal link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data