dodecadienoate (12:2)* to indoleacetylglutamine

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of indoleacetylglutamine
Metabolite Accession: GCST90199817
Name: indoleacetylglutamine
Hmdb Id: HMDB0013240
Super Pathway: NA
Sub Pathway: NA
Inchikey: DVJIJAYHBZALOJ

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.278
Position:
151879761
SE (Ratio):
0.025
Effect Allele:
A
Z-score (Ratio):
-10.939
Reference Allele:
G
-log10(P):
-62.462
MAF:
0.318
Beta (Num):
-0.115
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.164
SE (Den):
0.018
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, dicarboxylate metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Tryptophan metabolism.5[1]

Ratio Explanation:

The ratio may indicate a balance between fatty acid metabolism, modulated by THEM4, and tryptophan catabolism, though a direct link is not established.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic regulation of THEM4, an acyl-CoA thioesterase, likely alters dodecadienoate levels by acting on its acyl-CoA form.1[1], 6[2] The change in the ratio with indoleacetylglutamine suggests a broad metabolic shift, but no associated phenotype is identified from the provided data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data