dodecadienoate (12:2)* to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Metabolite Accession: GCST90200101
Name: pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Hmdb Id: HMDB0013328
Super Pathway: NA
Sub Pathway: NA
Inchikey: NTBUXPPQHCFLOM

Associated Genomic Regions

Region: rs2999545

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.217
Position:
151904146
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-9.894
Reference Allele:
T
-log10(P):
-51.469
MAF:
0.388
Beta (Num):
-0.116
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.101
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid oxidation, Dicarboxylic acid metabolism3[1], 4[2], 5[3], 6[4]

Ratio Explanation:

This ratio may reflect peroxisomal beta-oxidation activity, where active THEM4 would reduce the denominator, pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc), relative to the numerator, dodecadienoate (12:2).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in THEM4 likely alters its expression, which impacts peroxisomal fatty acid oxidation and the balance between dodecadienoate and its downstream dicarboxylic acid metabolites. No phenotype data is available to establish a conclusive link.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data