dodecadienoate (12:2)* to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs1060870

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.170
Position:
151862661
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-10.854
Reference Allele:
A
-log10(P):
-61.527
MAF:
0.398
Beta (Num):
-0.117
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.052
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.7[1]

Ratio Explanation:

The ratio may reflect the efficiency of long-chain fatty acid transport into mitochondria, a process dependent on carnitine and influenced by SLC22A5 function.1[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function likely modifies fatty acid oxidation, which is essential for hematopoietic stem cell maintenance and differentiation.9[1], 10[2], 11[3] This can subsequently impact the production of various blood cells, leading to changes in monocyte, platelet, and other blood cell counts.12[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data