2-hydroxysebacate to 2-hydroxydecanoate

Numerator Metabolite

Structure of 2-hydroxysebacate
Metabolite Accession: GCST90200198
Name: 2-hydroxysebacate
Hmdb Id: HMDB0000424
Super Pathway: NA
Sub Pathway: NA
Inchikey: LPIOYESQKJFWPQ

Denominator Metabolite

Structure of 2-hydroxydecanoate
Metabolite Accession: GCST90199934
Name: 2-hydroxydecanoate
Hmdb Id: HMDB0094656
Super Pathway: NA
Sub Pathway: NA
Inchikey: GHPVDCPCKSNJDR

Associated Genomic Regions

Region: rs67392104

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.254
Position:
47393312
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-11.594
Reference Allele:
C
-log10(P):
-69.890
MAF:
0.110
Beta (Num):
-0.181
Novel Locus:
No
SE (Num):
0.025
Beta (Den):
0.072
SE (Den):
0.024
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.10[1], 11[2]

Ratio Explanation:

This ratio likely reflects the activity of fatty acid omega-oxidation, where CYP4B1 can hydroxylate C10 fatty acids, influencing the balance between these metabolites.6[1], 12[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype was provided, so a causal link between CYP4B1, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data