2-hydroxysebacate to glycine conjugate of c10h12o2*

Numerator Metabolite

Structure of 2-hydroxysebacate
Metabolite Accession: GCST90200198
Name: 2-hydroxysebacate
Hmdb Id: HMDB0000424
Super Pathway: NA
Sub Pathway: NA
Inchikey: LPIOYESQKJFWPQ

Denominator Metabolite

Metabolite Accession: GCST90200182
Name: glycine conjugate of c10h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs3863632

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.343
Position:
47309833
SE (Ratio):
0.036
Effect Allele:
T
Z-score (Ratio):
-9.645
Reference Allele:
C
-log10(P):
-49.011
MAF:
0.113
Beta (Num):
-0.180
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.162
SE (Den):
0.027
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4B1 CYP4A11 CYP4X1 EFCAB14 ATPAF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Dicarboxylic acid glycine conjugation9[1], 10[2], 11[3]

Ratio Explanation:

This ratio may reflect omega-oxidation of C10 fatty acids (numerator) versus the subsequent glycine conjugation of the resulting dicarboxylic acid (denominator) for excretion.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data