6-bromotryptophan to 3-formylindole

Numerator Metabolite

Structure of 6-bromotryptophan
Metabolite Accession: GCST90200201
Name: 6-bromotryptophan
Hmdb Id: HMDB0242168
Super Pathway: NA
Sub Pathway: NA
Inchikey: OAORYCZPERQARS

Denominator Metabolite

Structure of 3-formylindole
Metabolite Accession: GCST90200184
Name: 3-formylindole
Hmdb Id: HMDB29737
Super Pathway: NA
Sub Pathway: NA
Inchikey: OLNJUISKUQQNIM

Associated Genomic Regions

Region: rs1165157

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.233
Position:
25792250
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-10.727
Reference Allele:
A
-log10(P):
-60.141
MAF:
0.302
Beta (Num):
-0.133
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.099
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism.11[1], 12[2], 13[3], 14[4], 15[5], 16[6]

Denominator Metabolite Explanation:

Tryptophan metabolism.17[1], 18[2], 19[3]

Ratio Explanation:

A higher ratio of 6-bromotryptophan to 3-formylindole may indicate altered tryptophan metabolism, potentially influenced by SLC17A1's role in transporting related metabolites or affecting renal function.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A1 gene influences uric acid levels, which is one of the associated phenotypes.3[1], 4[2], 7[3] Both 6-bromotryptophan and 3-formylindole are metabolites of tryptophan, and altered tryptophan metabolism has been linked to hematological characteristics.12[4], 14[5] Therefore, variations in SLC17A1 could impact tryptophan metabolism, leading to the observed ratio and phenotypes.

Phenotype Driver:

Gene-centric:SLC17A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data