indoleacetoylcarnitine* to indoleacetate

Numerator Metabolite

Metabolite Accession: GCST90200203
Name: indoleacetoylcarnitine*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of indoleacetate
Metabolite Accession: GCST90199683
Name: indoleacetate
Hmdb Id: HMDB0000197
Super Pathway: NA
Sub Pathway: NA
Inchikey: SEOVTRFCIGRIMH

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.226
Position:
151879761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
13.485
Reference Allele:
G
-log10(P):
-93.755
MAF:
0.320
Beta (Num):
0.155
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.070
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs7186805

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.299
Position:
20477163
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
17.429
Reference Allele:
G
-log10(P):
-154.981
MAF:
0.284
Beta (Num):
0.215
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.084
SE (Den):
0.017
No CNV overlap
rQTL cluster:
31
Reaction Distance:
NA
Closest Genes:
ACSM2A AC137056.1 ACSM5 PDILT ACSM2B

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan Metabolism, Carnitine Metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Tryptophan Metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the conversion of indoleacetate to indoleacetoylcarnitine, a process potentially influenced by ACSM2A-mediated activation of indoleacetate.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype link was provided in the input data, so no causal relationship can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data