indoleacetoylcarnitine* to indolepropionate

Numerator Metabolite

Metabolite Accession: GCST90200203
Name: indoleacetoylcarnitine*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of indolepropionate
Metabolite Accession: GCST90199686
Name: indolepropionate
Hmdb Id: HMDB0002302
Super Pathway: NA
Sub Pathway: NA
Inchikey: GOLXRNDWAUTYKT

Associated Genomic Regions

Region: rs1910802

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.390
Position:
20475567
SE (Ratio):
0.026
Effect Allele:
A
Z-score (Ratio):
14.809
Reference Allele:
T
-log10(P):
-112.577
MAF:
0.284
Beta (Num):
0.217
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.173
SE (Den):
0.017
No CNV overlap
rQTL cluster:
31
Reaction Distance:
NA
Closest Genes:
ACSM2A ACSM5 AC137056.1 PDILT ACSM2B

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Tryptophan metabolism.5[1], 6[2], 7[3], 8[4], 9[5], 10[6]

Denominator Metabolite Explanation:

Tryptophan metabolism.11[1], 12[2], 13[3], 14[4]

Ratio Explanation:

This ratio may reflect a shift in tryptophan metabolism, where increased indoleacetate conjugation with carnitine (numerator) occurs relative to indolepropionate (denominator) production by gut microbiota.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data