indoleacetoylcarnitine* to 3-hydroxydecanoate

Numerator Metabolite

Metabolite Accession: GCST90200203
Name: indoleacetoylcarnitine*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.365
Position:
151879761
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
15.335
Reference Allele:
G
-log10(P):
-120.534
MAF:
0.320
Beta (Num):
0.155
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.210
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2], 7[3]

Ratio Explanation:

A lower ratio of indoleacetoylcarnitine to 3-hydroxydecanoate, influenced by THEM4's role in fatty acid metabolism, may reflect altered mitochondrial bioenergetics and tryptophan metabolism.1[1], 2[2], 5[3], 3[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The eQTL for THEM4, an acyl-CoA thioesterase involved in lipid metabolism, suggests a potential link between its function and the ratio of indoleacetoylcarnitine to the fatty acid metabolite 3-hydroxydecanoate, although no direct phenotype link is established.1[1], 2[2]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data