indoleacetoylcarnitine* to indolebutyrate

Numerator Metabolite

Metabolite Accession: GCST90200203
Name: indoleacetoylcarnitine*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of indolebutyrate
Metabolite Accession: GCST90199759
Name: indolebutyrate
Hmdb Id: HMDB0002096
Super Pathway: NA
Sub Pathway: NA
Inchikey: JTEDVYBZBROSJT

Associated Genomic Regions

Region: rs1910802

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.421
Position:
20475567
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
14.859
Reference Allele:
T
-log10(P):
-113.327
MAF:
0.284
Beta (Num):
0.217
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.205
SE (Den):
0.023
No CNV overlap
rQTL cluster:
31
Reaction Distance:
NA
Closest Genes:
ACSM2A ACSM5 AC137056.1 PDILT ACSM2B

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Tryptophan Metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Tryptophan and xenobiotic metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect the balance between different xenobiotic conjugation pathways of indole-derived compounds, potentially influenced by ACSM2A's activity on indoleacetate or indolebutyrate precursors.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a causal link between the genetic factors, the metabolite ratio, and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data