sulfate of piperine metabolite c18h21no3 (1)* to glucuronide of piperine metabolite c17h21no3 (3)*

Numerator Metabolite

Metabolite Accession: GCST90200206
Name: sulfate of piperine metabolite c18h21no3 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200189
Name: glucuronide of piperine metabolite c17h21no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174695

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
0.201
Position:
19947469
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
11.433
Reference Allele:
C
-log10(P):
-68.021
MAF:
0.451
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.175
SE (Den):
0.018
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Sulfation

Denominator Metabolite Explanation:

Xenobiotic Glucuronidation

Ratio Explanation:

The ratio reflects the relative activity of sulfation versus glucuronidation of a piperine metabolite; COMT likely influences the availability of the substrate for these competing pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No FinnGen or BioBank Japan phenotype data were provided, so a causal link between the COMT-driven piperine metabolite ratio and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data