sulfate of piperine metabolite c18h21no3 (1)* to glucuronide of piperine metabolite c17h21no3 (4)*

Numerator Metabolite

Metabolite Accession: GCST90200206
Name: sulfate of piperine metabolite c18h21no3 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200208
Name: glucuronide of piperine metabolite c17h21no3 (4)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174695

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
0.222
Position:
19947469
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
14.112
Reference Allele:
C
-log10(P):
-102.450
MAF:
0.451
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.196
SE (Den):
0.016
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Sulfation.4[1], 5[2]

Denominator Metabolite Explanation:

Xenobiotic metabolism, Glucuronidation.6[1], 7[2], 5[3]

Ratio Explanation:

This ratio reflects the balance between competing sulfation and glucuronidation xenobiotic pathways for piperine metabolites, a process potentially influenced by linked enzymatic activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation near COMT is associated with Type 2 diabetes.8[1], 9[2], 10[3], 11[4], 12[5] This variation may alter the balance of Phase II detoxification pathways, as indicated by the piperine metabolite ratio, and this altered metabolic capacity may contribute to T2D pathophysiology.13[6], 14[7], 15[8], 16[9]

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data