sulfate of piperine metabolite c18h21no3 (1)* to glucuronide of piperine metabolite c17h21no3 (5)*

Numerator Metabolite

Metabolite Accession: GCST90200206
Name: sulfate of piperine metabolite c18h21no3 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200212
Name: glucuronide of piperine metabolite c17h21no3 (5)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174695

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
0.210
Position:
19947469
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
11.870
Reference Allele:
C
-log10(P):
-73.152
MAF:
0.451
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.184
SE (Den):
0.018
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Sulfation

Denominator Metabolite Explanation:

Xenobiotic metabolism, Glucuronidation

Ratio Explanation:

This ratio reflects the balance between sulfation and glucuronidation, two competing Phase II xenobiotic metabolism pathways for piperine metabolites.2[1], 3[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in COMT is associated with altered catecholamine metabolism and type 2 diabetes risk.4[1], 5[2] The metabolite ratio is likely a biomarker of COMT genotype and its associated metabolic activity rather than being directly causal for diabetes.

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data