glucuronide of piperine metabolite c17h21no3 (4)* to piperine

Numerator Metabolite

Metabolite Accession: GCST90200208
Name: glucuronide of piperine metabolite c17h21no3 (4)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of piperine
Metabolite Accession: GCST90199729
Name: piperine
Hmdb Id: HMDB0029377
Super Pathway: NA
Sub Pathway: NA
Inchikey: MXXWOMGUGJBKIW

Associated Genomic Regions

Region: rs174695

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
-0.173
Position:
19947469
SE (Ratio):
0.012
Effect Allele:
T
Z-score (Ratio):
-14.869
Reference Allele:
C
-log10(P):
-113.469
MAF:
0.449
Beta (Num):
-0.196
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.024
SE (Den):
0.016
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Glucuronidation7[1], 8[2], 9[3], 10[4], 11[5], 12[6], 13[7]

Denominator Metabolite Explanation:

Xenobiotic metabolism14[1], 15[2], 16[3], 17[4]

Ratio Explanation:

The ratio reflects piperine metabolism via glucuronidation.18[1], 14[2], 10[3], 19[4], 13[5] Piperine inhibits the glucuronidation process, which can increase the bioavailability of other substances.18[6], 10[7], 19[8], 15[9], 13[10], 20[11]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in COMT are associated with alterations in catecholamine levels and have been linked to type 2 diabetes risk.21[1], 22[2], 23[3], 24[4], 25[5] Piperine itself may influence glucose metabolism and insulin sensitivity.26[6], 27[7], 28[8], 29[9] The link may be through COMT's role in systemic metabolic regulation, influenced by xenobiotics like piperine.

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data