glucuronide of piperine metabolite c17h21no3 (4)* to sulfate of piperine metabolite c16h19no3 (3)*

Numerator Metabolite

Metabolite Accession: GCST90200208
Name: glucuronide of piperine metabolite c17h21no3 (4)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200209
Name: sulfate of piperine metabolite c16h19no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs143647521

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.553
Position:
28555161
SE (Ratio):
0.065
Effect Allele:
T
Z-score (Ratio):
8.545
Reference Allele:
C
-log10(P):
-38.890
MAF:
0.010
Beta (Num):
0.282
Novel Locus:
Yes ✔️
SE (Num):
0.078
Beta (Den):
-0.270
SE (Den):
0.082
No CNV overlap
rQTL cluster:
176
Reaction Distance:
NA
Closest Genes:
NUPR1 CCDC101 IL27 APOBR SULT1A2

Region: rs4680

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
0.251
Position:
19951271
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
19.660
Reference Allele:
A
-log10(P):
-196.474
MAF:
0.486
Beta (Num):
0.166
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.086
SE (Den):
0.016
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Metabolism (Glucuronidation)7[1], 8[2], 9[3], 10[4], 11[5]

Denominator Metabolite Explanation:

Xenobiotic Metabolism (Sulfation)7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio reflects competing glucuronidation and sulfation pathways for piperine metabolites, where genetic variants in SULT1A1 likely modulate sulfation efficiency.1[1], 7[2], 10[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in SULT1A1 alters sulfation capacity for numerous substrates, reflected by the piperine metabolite ratio.12[1] This pleiotropic effect likely underlies associations with renal failure and Type 2 diabetes by affecting the clearance of uremic toxins or altering endogenous molecule metabolism.13[2], 14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:SULT1A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data