glucuronide of piperine metabolite c17h21no3 (4)* to sulfate of piperine metabolite c16h19no3 (2)*

Numerator Metabolite

Metabolite Accession: GCST90200208
Name: glucuronide of piperine metabolite c17h21no3 (4)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200210
Name: sulfate of piperine metabolite c16h19no3 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs143647521

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.545
Position:
28555161
SE (Ratio):
0.061
Effect Allele:
T
Z-score (Ratio):
8.940
Reference Allele:
C
-log10(P):
-42.394
MAF:
0.010
Beta (Num):
0.282
Novel Locus:
Yes ✔️
SE (Num):
0.078
Beta (Den):
-0.263
SE (Den):
0.080
No CNV overlap
rQTL cluster:
176
Reaction Distance:
NA
Closest Genes:
NUPR1 CCDC101 IL27 APOBR SULT1A2

Region: rs174695

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
-0.254
Position:
19947469
SE (Ratio):
0.012
Effect Allele:
T
Z-score (Ratio):
-20.358
Reference Allele:
C
-log10(P):
-210.466
MAF:
0.449
Beta (Num):
-0.196
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.057
SE (Den):
0.016
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic glucuronidation

Denominator Metabolite Explanation:

Xenobiotic sulfation

Ratio Explanation:

This ratio reflects the balance between two major phase II detoxification pathways, glucuronidation and sulfation, for piperine metabolites.5[1], 6[2], 7[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SULT1A1/COMT activity, indicated by the piperine metabolite ratio, may influence the metabolism of endogenous compounds like catecholamines and steroids.8[1], 1[2], 9[3] This dysregulation is a proposed mechanism affecting glucose homeostasis and risk for Type 2 diabetes.10[4], 9[5], 11[6]

Phenotype Driver:

Gene-centric:SULT1A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data