glucuronide of piperine metabolite c17h21no3 (4)* to sulfate of piperine metabolite c18h21no3 (3)*

Numerator Metabolite

Metabolite Accession: GCST90200208
Name: glucuronide of piperine metabolite c17h21no3 (4)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200216
Name: sulfate of piperine metabolite c18h21no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174695

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
-0.223
Position:
19947469
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-13.900
Reference Allele:
C
-log10(P):
-99.463
MAF:
0.449
Beta (Num):
-0.196
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.027
SE (Den):
0.017
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Piperine Glucuronidation7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Piperine Sulfation7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects the balance between two major piperine detoxification pathways, glucuronidation and sulfation, potentially influenced by COMT activity.7[1], 8[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

COMT gene variants are associated with type 2 diabetes.6[1], 10[2], 11[3], 12[4], 13[5] Piperine also shows potential in mitigating diabetes.14[6], 15[7], 16[8], 17[9] Altered COMT activity may influence piperine metabolism, affecting its bioactivity and the subsequent link to diabetes, although the direct causal chain is not fully established.

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data