sulfate of piperine metabolite c16h19no3 (3)* to piperine

Numerator Metabolite

Metabolite Accession: GCST90200209
Name: sulfate of piperine metabolite c16h19no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of piperine
Metabolite Accession: GCST90199729
Name: piperine
Hmdb Id: HMDB0029377
Super Pathway: NA
Sub Pathway: NA
Inchikey: MXXWOMGUGJBKIW

Associated Genomic Regions

Region: rs4148325

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
2
Beta (Ratio):
0.083
Position:
234673309
SE (Ratio):
0.011
Effect Allele:
T
Z-score (Ratio):
7.637
Reference Allele:
C
-log10(P):
-31.441
MAF:
0.325
Beta (Num):
0.084
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
5.88e-04
SE (Den):
0.017
No CNV overlap
rQTL cluster:
138
Reaction Distance:
NA
Closest Genes:
UGT1A10 UGT1A3 UGT1A5 UGT1A8 UGT1A1

Region: rs4680

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
22
Beta (Ratio):
-0.095
Position:
19951271
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
-9.326
Reference Allele:
A
-log10(P):
-45.954
MAF:
0.485
Beta (Num):
-0.086
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.009
SE (Den):
0.016
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Metabolism, Sulfation.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Xenobiotic Metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects the metabolic conversion of piperine to a sulfated metabolite. COMT's involvement suggests it may methylate a catechol intermediate of piperine, affecting substrate availability for sulfation.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

COMT gene variants can alter estrogen metabolism, a known risk factor for cholelithiasis.9[1], 10[2], 11[3] This hormonal influence, rather than the piperine ratio itself, likely explains the association with gallstones (cholelithiasis) and related biliary phenotypes.

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data