sulfate of piperine metabolite c16h19no3 (3)* to glucuronide of piperine metabolite c17h21no3 (3)*

Numerator Metabolite

Metabolite Accession: GCST90200209
Name: sulfate of piperine metabolite c16h19no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200189
Name: glucuronide of piperine metabolite c17h21no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174695

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
0.237
Position:
19947469
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
14.742
Reference Allele:
C
-log10(P):
-111.586
MAF:
0.451
Beta (Num):
0.062
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.175
SE (Den):
0.018
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic sulfation

Denominator Metabolite Explanation:

Xenobiotic glucuronidation

Ratio Explanation:

The ratio reflects the balance between sulfation and glucuronidation of piperine metabolites, with COMT potentially influencing the availability of catechol substrates for these competing pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in COMT is associated with Type 2 diabetes.2[1], 3[2], 4[3], 5[4], 6[5] A lower ratio of sulfated to glucuronidated piperine metabolites, potentially influenced by COMT activity, may be associated with altered piperine metabolism, which has been linked to glucose homeostasis and Type 2 diabetes.7[6], 8[7], 9[8], 10[9], 11[10]

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data