sulfate of piperine metabolite c16h19no3 (3)* to glucuronide of piperine metabolite c17h21no3 (5)*

Numerator Metabolite

Metabolite Accession: GCST90200209
Name: sulfate of piperine metabolite c16h19no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200212
Name: glucuronide of piperine metabolite c17h21no3 (5)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4680

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
-0.241
Position:
19951271
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-15.230
Reference Allele:
A
-log10(P):
-118.935
MAF:
0.485
Beta (Num):
-0.086
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.155
SE (Den):
0.017
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic sulfation3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Xenobiotic glucuronidation6[1], 7[2], 4[3], 5[4]

Ratio Explanation:

The ratio reflects the balance between two major phase II detoxification pathways for piperine metabolites; COMT pQTL suggests a potential upstream influence on substrate availability.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in COMT may alter the metabolism of catecholamines, which have been linked to blood pressure regulation and renal function.8[1], 9[2], 10[3] Higher pulse pressure and altered COMT activity are associated with type 2 diabetes and renal failure.11[4], 12[5], 8[6], 13[7]

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data