sulfate of piperine metabolite c16h19no3 (2)* to piperine

Numerator Metabolite

Metabolite Accession: GCST90200210
Name: sulfate of piperine metabolite c16h19no3 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of piperine
Metabolite Accession: GCST90199729
Name: piperine
Hmdb Id: HMDB0029377
Super Pathway: NA
Sub Pathway: NA
Inchikey: MXXWOMGUGJBKIW

Associated Genomic Regions

Region: rs165722

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
-0.091
Position:
19949013
SE (Ratio):
0.009
Effect Allele:
C
Z-score (Ratio):
-10.364
Reference Allele:
T
-log10(P):
-56.275
MAF:
0.483
Beta (Num):
-0.080
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.011
SE (Den):
0.016
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Metabolism, Sulfation3[1], 4[2]

Denominator Metabolite Explanation:

Xenobiotic Metabolism5[1]

Ratio Explanation:

The ratio reflects the efficiency of piperine metabolism via sulfation, a process that can compete with COMT-mediated methylation for piperine's hydroxylated metabolites.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in COMT alters its function in metabolizing catecholamines, which can directly impact blood pressure regulation and glucose metabolism, leading to increased risk for pulse pressure and type 2 diabetes.6[1], 7[2], 8[3] The piperine ratio likely acts as a biomarker for COMT activity.

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data