sulfate of piperine metabolite c16h19no3 (2)* to glucuronide of piperine metabolite c17h21no3 (3)*

Numerator Metabolite

Metabolite Accession: GCST90200210
Name: sulfate of piperine metabolite c16h19no3 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200189
Name: glucuronide of piperine metabolite c17h21no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174695

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
0.232
Position:
19947469
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
14.213
Reference Allele:
C
-log10(P):
-103.883
MAF:
0.450
Beta (Num):
0.057
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.175
SE (Den):
0.018
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Piperine metabolism

Denominator Metabolite Explanation:

Xenobiotic metabolism, Piperine metabolism

Ratio Explanation:

The ratio reflects the balance between sulfation and glucuronidation of piperine metabolites, potentially influenced by COMT activity, although direct catalysis is not established.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

COMT genetic variants influence its enzymatic activity, which is associated with Type 2 diabetes risk.3[1], 4[2], 5[3], 6[4], 7[5] Piperine and its metabolites, while not directly metabolized by COMT, have shown potential effects on glucose metabolism and insulin sensitivity, suggesting a complex interaction.8[6], 9[7], 10[8], 11[9], 12[10]

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data