sulfate of piperine metabolite c16h19no3 (2)* to glucuronide of piperine metabolite c17h21no3 (5)*

Numerator Metabolite

Metabolite Accession: GCST90200210
Name: sulfate of piperine metabolite c16h19no3 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200212
Name: glucuronide of piperine metabolite c17h21no3 (5)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4680

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
-0.235
Position:
19951271
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-14.385
Reference Allele:
A
-log10(P):
-106.363
MAF:
0.486
Beta (Num):
-0.080
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.155
SE (Den):
0.017
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Sulfation of piperine metabolites.2[1], 3[2]

Denominator Metabolite Explanation:

Glucuronidation of piperine metabolites.2[1], 4[2], 3[3]

Ratio Explanation:

This ratio reflects the balance between two major phase II detoxification pathways for piperine metabolites, sulfation and glucuronidation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

COMT genetic variants influence catecholamine levels, which are linked to blood pressure and renal function.5[1], 6[2], 7[3], 8[4] Altered COMT activity may impact piperine metabolism and detoxification, potentially influencing renal function and diabetes risk, though the direct link is still under investigation.5[5], 9[6], 10[7], 11[8]

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data