glucuronide of piperine metabolite c17h21no3 (5)* to sulfate of piperine metabolite c18h21no3 (3)*

Numerator Metabolite

Metabolite Accession: GCST90200212
Name: glucuronide of piperine metabolite c17h21no3 (5)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200216
Name: sulfate of piperine metabolite c18h21no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4680

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
0.204
Position:
19951271
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
12.011
Reference Allele:
A
-log10(P):
-74.848
MAF:
0.496
Beta (Num):
0.155
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.049
SE (Den):
0.017
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Glucuronidation

Denominator Metabolite Explanation:

Xenobiotic metabolism, Sulfation

Ratio Explanation:

This ratio reflects the balance between two major phase II detoxification pathways for piperine metabolites, glucuronidation and sulfation, potentially influenced by upstream COMT activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in COMT, which alters catecholamine metabolism, is the likely primary driver of the associated phenotypes (Type 2 diabetes, renal failure, pulse pressure). The piperine metabolite ratio serves as a biomarker for COMT activity rather than being a direct causal factor.4[1], 5[2], 6[3], 7[4]

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data