11beta-hydroxyandrosterone glucuronide to etiocholanolone glucuronide

Numerator Metabolite

Structure of 11beta-hydroxyandrosterone glucuronide
Metabolite Accession: GCST90200214
Name: 11beta-hydroxyandrosterone glucuronide
Hmdb Id: HMDB0010351
Super Pathway: NA
Sub Pathway: NA
Inchikey: BRPLOVMHAFXVOQ

Denominator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs72790679

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.872
Position:
31654155
SE (Ratio):
0.069
Effect Allele:
A
Z-score (Ratio):
-12.558
Reference Allele:
G
-log10(P):
-81.608
MAF:
0.017
Beta (Num):
-0.455
Novel Locus:
No
SE (Num):
0.057
Beta (Den):
0.417
SE (Den):
0.058
No CNV overlap
rQTL cluster:
150
Reaction Distance:
NA
Closest Genes:
XDH EHD3 CAPN14 GALNT14 MEMO1

Region: rs113017476

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.705
Position:
31989359
SE (Ratio):
0.049
Effect Allele:
A
Z-score (Ratio):
-14.286
Reference Allele:
G
-log10(P):
-104.931
MAF:
0.035
Beta (Num):
-0.420
Novel Locus:
No
SE (Num):
0.040
Beta (Den):
0.285
SE (Den):
0.041
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 SPAST XDH SLC30A6

Region: rs74364753

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.802
Position:
32693881
SE (Ratio):
0.073
Effect Allele:
G
Z-score (Ratio):
-11.055
Reference Allele:
C
-log10(P):
-63.746
MAF:
0.015
Beta (Num):
-0.417
Novel Locus:
No
SE (Num):
0.059
Beta (Den):
0.385
SE (Den):
0.060
No CNV overlap
rQTL cluster:
150
Reaction Distance:
NA
Closest Genes:
BIRC6 YIPF4 TTC27 NLRC4 SLC30A6

LLM Analysis

Numerator Metabolite Explanation:

Androgen and glucocorticoid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Androgen and progesterone metabolism.6[1], 7[2]

Ratio Explanation:

This ratio may reflect the relative activity between androgen and glucocorticoid breakdown pathways, which could indicate the functional status of enzymes like 11β-hydroxysteroid dehydrogenase. 8[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between YIPF4, the specified metabolite ratio, and a clinical phenotype cannot be established from the given data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data