11beta-hydroxyandrosterone glucuronide to cortolone glucuronide (1)

Numerator Metabolite

Structure of 11beta-hydroxyandrosterone glucuronide
Metabolite Accession: GCST90200214
Name: 11beta-hydroxyandrosterone glucuronide
Hmdb Id: HMDB0010351
Super Pathway: NA
Sub Pathway: NA
Inchikey: BRPLOVMHAFXVOQ

Denominator Metabolite

Structure of cortolone glucuronide (1)
Metabolite Accession: GCST90200156
Name: cortolone glucuronide (1)
Hmdb Id: HMDB0010320
Super Pathway: NA
Sub Pathway: NA
Inchikey: OKNSFVSKHQJVRN

Associated Genomic Regions

Region: rs112875651

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
8
Beta (Ratio):
-0.117
Position:
126506694
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-7.535
Reference Allele:
G
-log10(P):
-30.649
MAF:
0.392
Beta (Num):
-0.053
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.063
SE (Den):
0.015
No CNV overlap
rQTL cluster:
83
Reaction Distance:
NA
Closest Genes:
TRIB1 NSMCE2 KIAA0196 SQLE ZNF572

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Steroid Metabolism.4[1], 5[2], 6[3], 7[4], 8[5]

Denominator Metabolite Explanation:

Corticosteroid and Steroid Metabolism.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

The ratio reflects the relative activity of androgen versus cortisol metabolism, which are downstream pathways influenced by upstream cholesterol synthesis regulated by SQLE.9[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Increased SQLE activity drives cholesterol synthesis, directly contributing to hypercholesterolemia, coronary atherosclerosis, and cholelithiasis.13[1], 14[2], 15[3], 16[4] The altered steroid ratio is a likely downstream effect of the primary dysregulation in cholesterol metabolism driven by SQLE.9[5], 17[6], 18[7]

Phenotype Driver:

Gene-centric:SQLE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data