sulfate of piperine metabolite c18h21no3 (3)* to glucuronide of piperine metabolite c17h21no3 (3)*

Numerator Metabolite

Metabolite Accession: GCST90200216
Name: sulfate of piperine metabolite c18h21no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200189
Name: glucuronide of piperine metabolite c17h21no3 (3)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174695

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Clumped rQTL variant

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SNP Summary

Chr:
22
Beta (Ratio):
0.202
Position:
19947469
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
11.500
Reference Allele:
C
-log10(P):
-68.795
MAF:
0.450
Beta (Num):
0.027
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.175
SE (Den):
0.018
No CNV overlap
rQTL cluster:
3
Reaction Distance:
NA
Closest Genes:
COMT ARVCF TXNRD2 TANGO2 GNB1L

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, sulfation.3[1], 4[2]

Denominator Metabolite Explanation:

Xenobiotic metabolism, glucuronidation.5[1], 6[2], 3[3], 4[4]

Ratio Explanation:

The ratio reflects competing sulfation and glucuronidation pathways of piperine metabolism, potentially influenced upstream by COMT activity on catechol-like precursors.7[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in COMT alters its activity, likely shifting the balance of piperine metabolism between sulfation and glucuronidation.7[1], 4[2] This altered xenobiotic handling, potentially affecting catecholamine levels, is colocalized with and may contribute to the risk for Type 2 diabetes.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:COMT

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data