cholic acid glucuronide to epiandrosterone sulfate

Numerator Metabolite

Structure of cholic acid glucuronide
Metabolite Accession: GCST90200219
Name: cholic acid glucuronide
Hmdb Id: HMDB0002577
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBLDVEUUCHVWMW

Denominator Metabolite

Structure of epiandrosterone sulfate
Metabolite Accession: GCST90199752
Name: epiandrosterone sulfate
Hmdb Id: HMDB0062657
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs62317882

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.423
Position:
69355709
SE (Ratio):
0.032
Effect Allele:
T
Z-score (Ratio):
-13.111
Reference Allele:
C
-log10(P):
-88.748
MAF:
0.245
Beta (Num):
-0.330
Novel Locus:
No
SE (Num):
0.028
Beta (Den):
0.093
SE (Den):
0.015
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Bile acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen and steroid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio reflects the balance between bile acid conjugation and androgen derivative sulfation, influenced by UGT enzyme activity.3[1], 6[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The UGT2B15/UGT2B17 genes are involved in the glucuronidation of androgens and estrogens.6[1], 1[2] Altered activity of these enzymes, potentially influenced by genetic variations, can affect hormone levels and the metabolism of dietary compounds, which may relate to the risk of benign colon neoplasms and impact cholesterol and liver enzyme levels.7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:UGT2B15/UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data