cholic acid glucuronide to 5alpha-androstan-3alpha,17alpha-diol monosulfate

Numerator Metabolite

Structure of cholic acid glucuronide
Metabolite Accession: GCST90200219
Name: cholic acid glucuronide
Hmdb Id: HMDB0002577
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBLDVEUUCHVWMW

Denominator Metabolite

Structure of 5alpha-androstan-3alpha,17alpha-diol monosulfate
Metabolite Accession: GCST90199850
Name: 5alpha-androstan-3alpha,17alpha-diol monosulfate
Hmdb Id: HMDB0000412
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBMYJHIOYJEBSB

Associated Genomic Regions

Region: rs62317882

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.601
Position:
69355709
SE (Ratio):
0.033
Effect Allele:
T
Z-score (Ratio):
-18.141
Reference Allele:
C
-log10(P):
-167.675
MAF:
0.245
Beta (Num):
-0.330
Novel Locus:
No
SE (Num):
0.028
Beta (Den):
0.271
SE (Den):
0.018
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism6[1]

Denominator Metabolite Explanation:

Androgen metabolism7[1]

Ratio Explanation:

The ratio reflects the balance of UGT-mediated glucuronidation of cholic acid against the metabolism (including sulfation and glucuronidation) of an androgen metabolite.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in UGT2B15/UGT2B17 alter the glucuronidation of bile acids and androgens.8[1], 1[2], 2[3] Dysregulated levels of these metabolites can impact liver function (ALT, ALP), lipid profiles (TC, LDL-C, HDL-C), and are associated with benign colorectal neoplasms.3[4], 4[5], 5[6], 9[7], 10[8], 11[9], 12[10]

Phenotype Driver:

Gene-centric:UGT2B15/UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data