cholic acid glucuronide to androstenediol (3alpha, 17alpha) monosulfate (3)

Numerator Metabolite

Structure of cholic acid glucuronide
Metabolite Accession: GCST90200219
Name: cholic acid glucuronide
Hmdb Id: HMDB0002577
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBLDVEUUCHVWMW

Denominator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs34164133

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
4
Beta (Ratio):
-0.518
Position:
69355334
SE (Ratio):
0.032
Effect Allele:
C
Z-score (Ratio):
-16.329
Reference Allele:
T
-log10(P):
-136.347
MAF:
0.245
Beta (Num):
-0.330
Novel Locus:
No
SE (Num):
0.028
Beta (Den):
0.187
SE (Den):
0.014
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism, Glucuronidation5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Androgen metabolism, Sulfation8[1], 9[2], 10[3]

Ratio Explanation:

Reflects the balance between bile acid glucuronidation and androgen sulfation, likely influenced by the activity of UGT enzymes like UGT2B17.1[1], 4[2], 11[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in UGT2B17 likely alters detoxification of bile acids and steroids.1[1], 12[2], 4[3] This dysregulation can impact cholesterol metabolism (lipid traits) and colonic exposure to mitogens, potentially increasing risk for benign colorectal neoplasms.13[4], 14[5], 15[6], 16[7], 17[8]

Phenotype Driver:

Gene-centric:UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data