cholic acid glucuronide to 5alpha-androstan-3alpha,17beta-diol monosulfate (1)

Numerator Metabolite

Structure of cholic acid glucuronide
Metabolite Accession: GCST90200219
Name: cholic acid glucuronide
Hmdb Id: HMDB0002577
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBLDVEUUCHVWMW

Denominator Metabolite

Metabolite Accession: GCST90199858
Name: 5alpha-androstan-3alpha,17beta-diol monosulfate (1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs62317882

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.497
Position:
69355709
SE (Ratio):
0.033
Effect Allele:
T
Z-score (Ratio):
-15.226
Reference Allele:
C
-log10(P):
-118.871
MAF:
0.245
Beta (Num):
-0.330
Novel Locus:
No
SE (Num):
0.028
Beta (Den):
0.167
SE (Den):
0.016
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism

Denominator Metabolite Explanation:

Androgen steroidogenesis

Ratio Explanation:

This ratio reflects competing glucuronidation by UGT2B enzymes on cholic acid versus an androgen metabolite, impacting their systemic levels and subsequent signaling.1[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in UGT2B17/UGT2B15 alters the metabolism of both bile acids and androgens. This dysregulation is linked to altered cholesterol levels, liver function markers, and increased risk for benign colorectal neoplasms, where both metabolite classes are implicated.5[1], 6[2], 7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data