cholic acid glucuronide to androsterone sulfate

Numerator Metabolite

Structure of cholic acid glucuronide
Metabolite Accession: GCST90200219
Name: cholic acid glucuronide
Hmdb Id: HMDB0002577
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBLDVEUUCHVWMW

Denominator Metabolite

Structure of androsterone sulfate
Metabolite Accession: GCST90200674
Name: androsterone sulfate
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs62317882

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.478
Position:
69355709
SE (Ratio):
0.032
Effect Allele:
T
Z-score (Ratio):
-14.777
Reference Allele:
C
-log10(P):
-112.104
MAF:
0.245
Beta (Num):
-0.330
Novel Locus:
No
SE (Num):
0.028
Beta (Den):
0.148
SE (Den):
0.016
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism, Glucuronidation.4[1], 5[2]

Denominator Metabolite Explanation:

Androgen metabolism, Sulfation.6[1], 7[2]

Ratio Explanation:

This ratio reflects the relative activity of glucuronidation versus sulfation pathways for bile acids and androgens, influenced by competition for enzymes like UGT2B17.1[1], 7[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in UGT2B17/UGT2B15 alters bile acid and androgen conjugation.1[1], 2[2], 9[3] This dysregulation impacts enterohepatic circulation and lipid homeostasis, influencing risk for colorectal neoplasms and altering cholesterol and liver enzyme levels.10[4], 11[5], 12[6], 13[7]

Phenotype Driver:

Gene-centric:UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data