4-methylhexanoylglutamine to 3-methyladipate

Numerator Metabolite

Metabolite Accession: GCST90200223
Name: 4-methylhexanoylglutamine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-methyladipate
Metabolite Accession: GCST90199829
Name: 3-methyladipate
Hmdb Id: HMDB0000555
Super Pathway: NA
Sub Pathway: NA
Inchikey: SYEOWUNSTUDKGM

Associated Genomic Regions

Region: rs59569607;rs1937130

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.187
Position:
25787554
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-8.332
Reference Allele:
T
-log10(P):
-37.071
MAF:
0.415
Beta (Num):
-0.105
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.082
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acyl glutamine)4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism (dicarboxylic acid)6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect a shift in fatty acid metabolism, but a direct link between the metabolites and SLC17A4 function is not established.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant likely alters uric acid transport, leading to changes in serum uric acid levels.1[1], 2[2], 3[3] This gene is also associated with red blood cell phenotypes, which could explain the link to MCH, Hb, MCV, and MCHC.9[4], 10[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data