4-methylhexanoylglutamine to androstenediol (3beta,17beta) disulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90200223
Name: 4-methylhexanoylglutamine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs12212049

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.200
Position:
25759066
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-8.734
Reference Allele:
G
-log10(P):
-40.550
MAF:
0.400
Beta (Num):
-0.110
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.090
SE (Den):
0.014
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A4 SLC17A1 HIST1H2BA HIST1H2AA SCGN

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, acyl-glutamine conjugation.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Steroid hormone metabolism, steroid sulfation.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio may reflect altered renal clearance of structurally unrelated metabolites due to SLC17A4's role as a multispecific transporter in the kidney and intestine.2[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 variant likely alters renal transport, directly impacting the observed phenotypes of uric acid and creatinine, and may secondarily influence red blood cell indices.11[1], 12[2]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data