4-methylhexanoylglutamine to heptenedioate (c7:1-dc)*

Numerator Metabolite

Metabolite Accession: GCST90200223
Name: 4-methylhexanoylglutamine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200163
Name: heptenedioate (c7:1-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs3799340

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.167
Position:
25762646
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-8.209
Reference Allele:
C
-log10(P):
-36.037
MAF:
0.414
Beta (Num):
-0.106
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.061
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A4 SLC17A1 HIST1H2BA HIST1H2AA SCGN

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glutamine)4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism6[1], 7[2]

Ratio Explanation:

The ratio may reflect altered transport of fatty acid metabolites by SLC17A4, but a direct relationship between these specific metabolites and the transporter is not established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC17A4, an organic anion transporter, may alter the transport of 4-methylhexanoylglutamine and heptenedioate, impacting pathways related to uric acid and red blood cell indices, thus influencing the observed phenotypes of serum creatinine, uric acid levels, and various red blood cell parameters.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data