4-methylhexanoylglutamine to 8-methoxykynurenate

Numerator Metabolite

Metabolite Accession: GCST90200223
Name: 4-methylhexanoylglutamine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 8-methoxykynurenate
Metabolite Accession: GCST90200186
Name: 8-methoxykynurenate
Hmdb Id: HMDB0060426
Super Pathway: NA
Sub Pathway: NA
Inchikey: BXZSKDOPGDPDEG

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.196
Position:
25802083
SE (Ratio):
0.024
Effect Allele:
C
Z-score (Ratio):
-8.329
Reference Allele:
T
-log10(P):
-37.043
MAF:
0.430
Beta (Num):
-0.101
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.094
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glutamine).10[1], 11[2], 12[3], 13[4], 14[5]

Denominator Metabolite Explanation:

Tryptophan Metabolism.15[1], 16[2], 17[3]

Ratio Explanation:

The ratio may reflect altered transport of organic anions by SLC17A4, potentially influencing both fatty acid and tryptophan metabolism, though a direct link is not established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene, an organic anion transporter, is associated with variations in uric acid and red blood cell indices. Altered transporter function may impact the levels of 4-methylhexanoylglutamine and 8-methoxykynurenate, metabolites linked to fatty acid and tryptophan pathways respectively, which could in turn influence hematological and metabolic phenotypes.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data