2-ketocaprylate to 2-hydroxyoctanoate

Numerator Metabolite

Structure of 2-ketocaprylate
Metabolite Accession: GCST90200224
Name: 2-ketocaprylate
Hmdb Id: HMDB13211
Super Pathway: NA
Sub Pathway: NA
Inchikey: GPPUPQFYDYLTIY

Denominator Metabolite

Structure of 2-hydroxyoctanoate
Metabolite Accession: GCST90199681
Name: 2-hydroxyoctanoate
Hmdb Id: HMDB0002264
Super Pathway: NA
Sub Pathway: NA
Inchikey: JKRDADVRIYVCCY

Associated Genomic Regions

Region: rs75939760

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.529
Position:
60570113
SE (Ratio):
0.041
Effect Allele:
C
Z-score (Ratio):
12.919
Reference Allele:
T
-log10(P):
-86.239
MAF:
0.012
Beta (Num):
0.349
Novel Locus:
No
SE (Num):
0.072
Beta (Den):
-0.180
SE (Den):
0.072
No CNV overlap
rQTL cluster:
203
Reaction Distance:
NA
Closest Genes:
PCNXL4 LRRC9 DHRS7 PPM1A RTN1

Region: rs77815174

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Clumped rQTL variant

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SNP Summary

Chr:
15
Beta (Ratio):
-0.188
Position:
76514896
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-11.848
Reference Allele:
T
-log10(P):
-72.895
MAF:
0.085
Beta (Num):
-0.147
Novel Locus:
Yes ✔️
SE (Num):
0.028
Beta (Den):
0.040
SE (Den):
0.028
No CNV overlap
rQTL cluster:
37
Reaction Distance:
NA
Closest Genes:
ETFA C15orf27 ISL2 SCAPER NRG4

Region: rs144025042

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.455
Position:
75148431
SE (Ratio):
0.043
Effect Allele:
A
Z-score (Ratio):
-10.520
Reference Allele:
G
-log10(P):
-57.923
MAF:
0.011
Beta (Num):
-0.450
Novel Locus:
Yes ✔️
SE (Num):
0.076
Beta (Den):
0.004
SE (Den):
0.076
No CNV overlap
rQTL cluster:
198
Reaction Distance:
NA
Closest Genes:
LDHD ZNRF1 ZFP1 CTRB2 CTRB1

LLM Analysis

Numerator Metabolite Explanation:

Amino acid metabolism5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid metabolism8[1], 9[2]

Ratio Explanation:

A higher ratio may suggest increased amino acid breakdown relative to fatty acid oxidation, with LDHD potentially influencing the level of 2-hydroxyoctanoate through its dehydrogenase activity.4[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data