3-hydroxyhexanoylcarnitine (1) to 3-hydroxysebacate

Numerator Metabolite

Structure of 3-hydroxyhexanoylcarnitine (1)
Metabolite Accession: GCST90200228
Name: 3-hydroxyhexanoylcarnitine (1)
Hmdb Id: HMDB0013131
Super Pathway: NA
Sub Pathway: NA
Inchikey: VYEONLJQPYRKAN

Denominator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Associated Genomic Regions

Region: rs57025390

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.298
Position:
47412477
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
12.271
Reference Allele:
C
-log10(P):
-78.028
MAF:
0.123
Beta (Num):
0.048
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.250
SE (Den):
0.025
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

Region: rs56078223

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.158
Position:
151898843
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
9.100
Reference Allele:
T
-log10(P):
-43.854
MAF:
0.294
Beta (Num):
0.050
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.108
SE (Den):
0.018
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

The ratio of 3-hydroxyhexanoylcarnitine (beta-oxidation intermediate) to 3-hydroxysebacate (omega-oxidation product) may reflect a shift in fatty acid metabolism, potentially influenced by THEM4's role as a thioesterase.4[1], 8[2], 9[3], 10[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Diverticular disease is associated with inflammation and alterations in gut microbiota, which can be influenced by fatty acid metabolism.11[1], 12[2], 13[3] THEM4's role in regulating fatty acid balance and signaling could causally link to this inflammatory phenotype.4[4], 7[5], 14[6]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data